Working Group: Topics
Topic: UGT1A1 Testing in Colorectal Cancer Patients to Predict Response to Irinotecan Therapy
EGAPP Recommendation: View Working Group Recommendation
Summary Article: Can UGT1A1 Genotyping Reduce Morbidity and Mortality in Patients with Metastatic Colorectal Cancer Treated with Irinotecan? (PDF 744KB) CDC/OPHG in collaboration with IPMMS.
Evidence Report: Can UGT1A1 Genotyping Reduce Morbidity and Mortality in Patients with Metastatic Colorectal Cancer Treated with Irinotecan? CDC, in conjunction with IPMMS and RTI
Other products: Pending
- Question 1: Does testing for UGT1A1 mutations in patients with metastatic CRC treated with irinotecan lead to improvement in outcomes? (Overarching question)
- Question 2: What is the analytic validity of the test(s) that identify key UGT1A1 mutations?
- Question 3: What is the clinical validity of UGT1A1 testing?
- Question 3a: How well does UGT1A1 testing predict phenotypic markers (e.g., increased plasma SN-38 levels or decreased enzyme activity) and associated adverse drug reactions (e.g., diarrhea or neutropenia)?
- Question 3b: How well does UGT1A1 testing in patients with metastatic CRC predict morbidity (diarrhea, neutropenia) and mortality (survival)?
- Question 3c: Do other factors (e.g., race/ethnicity, other medications) affect clinical validity?
- Question 4: What are the benefits and harms related to UGT1A1 testing for patients with metastatic CRC treated with irinotecan?
- Question 4a: Based on UGT1A1 test results, what are the management options for patients?
- Question 4b: Do these options improve patient outcomes or management decisions by patients or providers?
Why EGAPP Selected this topic for Review:
Key criteria: Prevalence and severity of colorectal cancer; irinotecan therapy is an increasingly common intervention; relevance to healthcare providers and patients for decision-making; FDA-approved test with potential impact on clinical practice.
Other Considerations: Limited literature that allows application of EGAPP methodology for a targeted review.
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Page last updated: May 15, 2013
Page last reviewed: May 15, 2013
Content Source: OPHG Staff